The production of the Alzheimer's-associated, toxic protein amyloid beta in the brain is tightly regulated by cholesterol in the cell membrane, advanced imaging reveals.
Eating a plant-centered diet during young adulthood is associated with a lower risk of heart disease in middle age, according to a long-term study with about 30 years of follow-up. A separate study with about 15 years of follow-up found that eating more plant-based foods that have been shown to lower cholesterol, called the 'Portfolio Diet', is associated with lower risk of cardiovascular disease in postmenopausal women.
Women often struggle with managing their weight and other health risk factors, such as high cholesterol, once they transition through menopause. A new study suggests that dancing may effectively lower cholesterol levels, improve fitness and body composition and in the process, improve self-esteem.
Using anonymized medical records from a national registry, researchers confirmed earlier findings that statins may substantially minimize adverse outcomes from SARS-CoV-2 infection.
Investigators conducted a systematic review and meta-analysis of 38 randomized controlled trials of omega-3 fatty acids. Overall, they found that omega-3 fatty acids improved cardiovascular outcomes. Results showed a significantly greater reduction in cardiovascular risk in studies of EPA alone rather than EPA+DHA supplements.
A typical Western high-fat diet can increase the risk of painful disorders common in people with conditions such as diabetes or obesity, according to a new study.
Researchers have found that high levels of a normal protein associated with reduced heart disease also protect against Alzheimer's-like damage in mice, opening up new approaches to slowing or stopping brain damage and cognitive decline in people with Alzheimer's.
People living with obesity who attended a non-judgemental and personalized lifestyle modification program improved their cardiovascular and mental health during just 10 weeks, according to a new study. Participants lost weight and achieved benefits in anxiety and depression and physical measurements including blood pressure.
Scientists studying the link between cholesterol and breast cancer report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.
Physical activity is the optimal first treatment choice for adults with mild to moderately elevated blood pressure and blood cholesterol who otherwise have low heart disease risk. About 21% of adults in the US with mild to moderately raised blood pressure and 28-37% of those with mild to moderate elevated cholesterol levels may be best served by a prescription for lifestyle-only treatment, which includes increasing physical activity.
A new study shows that tai chi mirrors the beneficial effects of conventional exercise by reducing waist circumference in middle-aged and older adults with central obesity.
The blood-brain barrier is impermeable to cholesterol, yet high blood cholesterol is associated with increased risk of Alzheimer's disease and vascular dementia. However, the underlying mechanisms mediating this relationship are poorly understood. A new study suggests that disturbances in the conversion of cholesterol to bile acids may play a role in the development of dementia.
Nearly half a billion people have diabetes, but most aren't getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data from people with the condition. Many don't even know they have the condition. Only 1 in 10 people with diabetes in the 55 low- and middle-income countries studied receive the type of comprehensive care that's been proven to reduce diabetes-related problems.
Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team has succeeded in sustainably lowering high LDL cholesterol levels in the blood of mice and macaques. This opens up the possibility of curing patients with inherited metabolic liver diseases.
Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it.
Having high blood pressure, high cholesterol and/or obesity from childhood through middle age were linked to poorer brain function by middle age. These cardiovascular risk factors were linked with low memory, learning, visual processing, attention span, and reaction and movement time. Strategies to prevent heart disease and stroke should begin in childhood to promote better brain health by middle age.
Vegetarians appear to have a healthier biomarker profile than meat-eaters, and this applies to adults of any age and weight, and is also unaffected by smoking and alcohol consumption, according to a new study in over 166,000 UK adults.
A team of researchers have identified a genetic mutation associated with exfoliation syndrome, characterized by abnormal protein material accumulating in the front of the eye. It is the most common cause of glaucoma, and a major cause of irreversible blindness. The findings could lead to further research on the causes of the systemic disorder and potential cures.