MRSA skin infections are often treated with intravenous injection of antibiotics, which can cause significant side effects and promote the development of resistant bacterial strains. To solve these problems, researchers are developing a microneedle patch that delivers antibiotics directly into the affected skin area. New results show that the microneedle patch effectively reduces MRSA bacteria in the skin.
As the human body's largest organ, the skin is responsible for protecting against a wide range of possible infections on all fleshy surfaces, from head to toe. So how exactly does the skin organize its defenses against such an array of threats?
A recent study monitors progress in the development of microneedles for immunotherapy and discusses the challenges regarding their production. Researchers suggest using microneedles for immunotherapy due to the abundance of immune cells under the skin. The aim is to vaccinate or treat different diseases, such as cancer and autoimmune disorders, with minimal invasiveness and side effects.
Scientists recently developed a new generation of microneedles technology which allows the intradermal delivery of living cells in a minimally invasive manner. Their experiment showed that vaccination using therapeutic cells through this ground-breaking technology elicited robust immune responses against tumors in mice, paving the way for developing an easy-to-use cell therapy and other therapeutics against cancers and other diseases.
Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product. Derived from platelets, the purified exosomal product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds. The research team documented restoration of skin integrity, hair follicles, sweat glands, skin oils and normal hydration.
Despite the prevalence of Alzheimer's, there are still no treatments, in part because it has been challenging to study how the disease develops. Now, scientists have uncovered new insights into what goes awry during Alzheimer's by growing neurons that resemble -- more accurately than ever before -- brain cells in older patients. And like patients themselves, the afflicted neurons appear to lose their cellular identity.
Fixing traumatic injuries to the skin and bones of the face and skull is difficult because of the many layers of different types of tissues involved, but now, researchers have repaired such defects in a rat model using bioprinting during surgery, and their work may lead to faster and better methods of healing skin and bones.
Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma.
Two new molecules that generate minute amounts of the gas hydrogen sulfide have been found to prevent skin from aging after being exposed to ultraviolet light found in sunlight. Sunburn is a major cause of premature aging in skin, and a primary risk factor for skin cancer, and other skin problems associated with aging. Now, an international research team has made inroads towards being able to reverse or delay this damage for the first time.
Researchers have developed a molecule that fluoresces where new tissue is forming in the body. Alongside helping to detect tumors, the molecule could play a significant role in research of wound healing disorders.
The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight -- not just a DNA copying error as previously believed, reports a new study. The findings upend long-held beliefs about the mechanisms underlying the disease, reinforce the importance of prevention efforts and offer a path forward for investigating the origins of other cancer types.
In a new study, Fralin Biomedical Research Institute at VTC scientists discovered that the alphaCT1 molecule may help repair the skin's collagen matrix by altering how scar-forming cells behave. The findings were published in the Federation of American Societies for Experimental Biology Journal.
Many people react to contact allergens, but some patients develop rashes and itching much faster than others. Previously the scientists were unable to explain why, but now researchers have outlined an entire new subgroup of allergic reactions which explains these early skin reactions. The new knowledge is vital to understanding the disease mechanisms in contact allergy.
New type of multifunctional wound dressings feature glowing nanosensors to track and monitor for infection. Harnessing the antimicrobial and anti-inflammatory power of magnesium hydroxide, the smart dressings can also fight bacteria and reduce inflammation to help promote healing.
Scientists have identified an internal communication network in mammals that may regulate tissue repair and inflammation, providing new insights on how diseases such as obesity and inflammatory skin disorders develop.
Researchers have designed a deep learning-based system that accurately identifies individual skin stem cells grown under artificial conditions and tracks their motion. Using this system to perform quality control of stem cell cultures could improve the speed and efficiency of growing skin grafts for use in regenerative medicine and may also be useful for other types of stem cell cultures.
Diet rich in sugar and fat leads to disruption in the gut's microbial culture and contributes to inflammatory skin diseases such as psoriasis. Research shows that switching to a more balanced diet restores the gut's health and suppresses inflammation.
A team of scientists has shown that the healing of skin blisters is driven by hair follicle stem cells, which delay their own development in the process.