It is essential for cells to control precisely which of the many genes of their genetic material they use. This is done in so-called transcription factories, molecular clusters in the nucleus. Researchers have now found that the formation of transcription factories resembles the condensation of liquids. Their findings will improve the understanding of causes of diseases and advance the development of DNA-based data storage systems.
A team of researchers has now demonstrated the existence of an internal diffusion barrier in the brain of fruit flies - in addition to the already known blood-brain barrier.
A new study reveals that pets can be infected with the alpha variant of SARS-CoV-2, which was first detected in southeast England and is commonly known as the UK variant or B.1.1.7.
A massive international research effort has led to development of a genetic model for the 'ultimate' chickpea, with the potential to lift crop yields by up to 12 per cent.
Scientists have sequenced the genome of the world's most widely used model plant species, Arabidopsis thaliana, at a level of detail never previously achieved. The study reveals the secrets of Arabidopsis chromosome regions called centromeres. The findings shed light on centromere evolution and provides insights into the genomic equivalent of black holes.
Pacific rockfish are among the longest-lived vertebrates -- some species live 200+ years. Yet others live barely 10. Their varied lifespans make rockfish a unique genus in which to pinpoint genes associated with long lifespan. Biologists sequenced and compared the genomes of 88 species and found longevity-related genes involved in living at depth and growing larger, but also an increase in some types of regulatory genes. Longer life also correlates with decreased population sizes.
Researchers have developed an injectable therapy based on nanofibers that has enabled paralyzed mice with severe spinal cord injuries to regain the ability to walk.
New research shows that humans had a significant role in the extinction of woolly mammoths in Eurasia, occurring thousands of years later than previously thought. An international team of scientists has revealed a 20,000-year pathway to extinction for the woolly mammoth.
Discoveries of iguanodontian dinosaurs from the Isle of Wight have previously only been assigned to Iguanodon or Mantellisaurus . The diversity of dinosaurs in the Early Cretaceous of the UK is much greater than previously thought.
The ability of cells to move together in harmony is crucial for numerous biological processes in our body, for example, wound healing, or the healthy development of an organism. This movement is made possible by the connections between individual cells. A research team has shown that particularly close connections -- 'tight junctions' -- play an important role in cell movement. In addition, researchers investigated the consequences of losing these connections.
Researchers have provided the first experimental evidence that brain regions can evolve independently of each other during cognitive evolution. This so called mosaic brain evolution was verified empirically in an artificial selection experiment with guppies (Poecilia reticulata) where telencephalon size (but no other regions) differed by 10 percent after only four generations of selection. The findings can have wide implications for the understanding of cognitive evolution in other vertebrates, such as primates and humans.
Human-caused bird extinctions are driving losses of functional diversity on islands worldwide, and the gaps they leave behind are not being filled by introduced (alien) species, finds a new study.
Comparing features of a common laboratory fruit fly with its rarer cousin collected from Hawai'i Volcanoes National Park, researchers used CRISPR technology to uncover clues about how high-level control genes called Hox genes shape our appearance.
A gene-silencing therapy protected against Zika virus transmission from pregnant mice to the mouse fetuses, finds a new study. The treatment, which harnesses nanoparticles called small extracellular vesicles (sEVs) for drug delivery, crossed the placenta and blood-brain barrier to greatly reduce fetal neurological damage, including virus-induced brain shrinkage.
Human neurons have a lower density of ion channels than expected, compared to neurons of other mammals, according to a new study. The researchers hypothesize that a lower channel density may have helped the human brain evolve to operate more efficiently.
Eukaryotic plankton are an essential and highly diverse component of marine ecosystems. A research team has established their global geographic distribution using DNA data and a probabilistic model. The study highlights large variations in geographic structure between plankton groups depending on their diversity, body size, and ecology, which can be linked to variations in sensitivity to local environmental conditions.
The amount and types of proteins our cells produce tell us important details about our health. Researchers have shown that it is possible to identify individual proteins with single-amino acid resolution and nearly 100% accuracy. Their method uses nanopores -- engineered openings that generate an electrical signal when molecules are pulled through by a specific enzyme.