Investigators found elevated levels of tau and a phosphorylated form of the tau protein in brain tissue from deceased people who had amyotrophic lateral sclerosis (ALS) and carried a mutation in the C9orf72 gene. The team also identified new genetic mutations in the tau gene that may exacerbate ALS onset or progression. Tau in the cerebrospinal fluid may be a viable biomarker for ALS because levels correlate with disease progression.
Researchers have trained computers to predict the next designer drugs before they are even on the market, technology that could save lives. Identifying these so-called 'legal highs' within seized pills or powders can take months, during which time thousands of people may have already used a new designer drug. But new research is already helping law enforcement agencies around the world to cut identification time down from months to days, crucial in the race to identify and regulate new versions of dangerous psychoactive drugs.
A large analysis of health records from 87 health care centers across the United States found that people taking a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs), particularly fluoxetine, were significantly less likely to die of COVID-19 than a matched control group.
New research has shown the drug losartan, normally used to treat high blood pressure (hypertension), is not effective in slowing down the progression of Alzheimer's disease (AD) in people with mild-to-moderate disease after 12 months of treatment. However, the drug could still be of benefit if prescribed for longer and if given to people with very early disease.
In a functional magnetic resonance imaging study of babies ranging in age from two to nine months, researchers have found regions of the infant visual cortex that show strong preferences for either faces, bodies, or scenes, just as they do in adults.
An undergraduate leads the discovery of a way to synthesize a rare molecule drawn from poppies. The molecule could become a building block for painkillers and other drugs.
A new study using genetically engineered mice and human cell and tissue samples has added to evidence that higher levels of inflammatory chemicals involved in fat metabolism occur in people with amyotrophic lateral sclerosis (ALS), the neuromuscular disorder, also known as Lou Gehrig's disease.
Doctors and scientists have successfully tested a neoantigen-specific transgenic immune cell therapy for malignant brain tumors for the first time using an experimental model in mice.
If you're a night owl looking to invest in the next big startup, making that decision first thing in the morning might not be the best idea, according to a new study.
The 24-hour news cycle and social media bombardment often resulting in conflicting messages about health issues might be making it harder than ever for people to make critical decisions, according to a new study.
Students who have repeated a grade have higher risks of being victims of bullying in countries around the world, according to a new study of nearly half a million students.
Researchers have developed an injectable therapy based on nanofibers that has enabled paralyzed mice with severe spinal cord injuries to regain the ability to walk.
Research suggested that autism spectrum disorder (ASD) may be at least partly caused by differences in the composition of the gut microbiota, based on the observation that certain types of microbes are more common in people with autism. But a new study suggests that the link may actually work the other way around: the diversity in species found in the guts of children with autism may be due to their restricted dietary preferences associated with autism, rather than the cause of their symptoms.
The outcome predictive models were developed in part using data from a large multi-center study. The findings provide strong evidence that the current trial-and-error approach used in clinical practice for the selection of the right antidepressant can be replaced with this new precision medicine approach.
Researchers have demonstrated that repeated listening to personally meaningful music induces beneficial brain plasticity in patients with mild cognitive impairment or early Alzheimer's disease.
Despite the belief that early diagnosis of Alzheimer's disease and other dementias is crucial, a new study found that the diagnosis may unintentionally impact social relationships and activity.
Researchers used a virtual-reality environment to understand the impact anxiety has on the brain and how brain regions interact with one another to shape behavior.
In an unexpected discovery, researchers have identified what appears to be a significant vascular defect in patients with moderately severe Parkinson's disease. The finding could help explain an earlier outcome of the same study, in which the drug nilotinib was able to halt motor and non-motor (cognition and quality of life) decline in the long term.
They say procrastination is the thief of time -- actually deadlines are. New research has found that if you want someone to help you out with something, it is best not to set a deadline at all. But if you do set a deadline, make it short.
A team of researchers has developed a new technique to open the blood-brain barrier temporarily to deliver medication to the brain. Getting medication past the brain's unique and protective blood vessels, known as the blood-brain barrier, is one of the biggest challenges in treating brain and central nervous system diseases, according to researchers. The technique uses light and nanoparticles to pry open temporarily these barriers -- called tight junctions -- to allow medication to reach its target.