Studying mice, researchers have developed a method of stem cell transplantation that does not require radiation or chemotherapy. Instead, the strategy takes an immunotherapeutic approach, combining the targeted elimination of blood-forming stem cells in the bone marrow with immune-modulating drugs to prevent the immune system from rejecting the new donor stem cells.
Our ability to understand the syntax of complex sentences is one of the most difficult language skills to acquire. In 2019, research had revealed a correlation between being particularly proficient in tool use and having good syntactic ability. A new study has now shown that both skills rely on the same neurological resources, which are located in the same brain region. Furthermore, motor training using a tool improves our ability to understand the syntax of complex sentences and -- vice-versa -- syntactic training improves our proficiency in using tools.
Scientists have sequenced the genome of the world's most widely used model plant species, Arabidopsis thaliana, at a level of detail never previously achieved. The study reveals the secrets of Arabidopsis chromosome regions called centromeres. The findings shed light on centromere evolution and provides insights into the genomic equivalent of black holes.
Advanced next-generation sequencing of autopsy tissues has furthered molecular understanding of SARS-CoV-2 infection and COVID-19 disease mechanisms, researchers report.
New research could significantly reduce overcrowding in emergency departments -- with great financial savings. Experts have developed a prediction model to identify patients most at risk of taking up hospital beds longer than needed.
A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, researchers have discovered. They report that inhibiting or genetically deleting the enzyme, called MTHFD2, reduced disease severity in multiple inflammatory disease models.
Volcanic eruptions contributed to the collapse of dynasties in China in the last 2,000 years by temporarily cooling the climate and affecting agriculture, according to a new study. Large eruptions create a cloud that blocks some sunlight for a year or two. That reduces warming of the land in Asia in the summer and leads to a weaker monsoon and less rainfall, reducing crop harvests.
When mothers and their children play together, they instinctively respond to each other's cues. And positive interactions promote the child's healthy socioemotional development. A new study examines how physiological and behavioral reactions coordinate during mother-child playtime. The findings highlight the importance of responsive communication, and can help provide insights for parents, practitioners, and researchers.
A new study reveals that common loud noises cause fluid buildup in the inner ear and suggests a simple possible treatment for noise-induced hearing loss.
A comprehensive study has shown that gene editing, specifically gene knockout (KO), with CRISPR-Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight the need to monitor patients undergoing CRISPR-Cas9-based gene therapy for cancer-related mutations.
Even when emoji are used to substitute for words, we still understand the sentence. But how does that work? Do we interpret an emoji primarily as an image or as a word? To find out, a research team asked volunteers to read texts with emoji and measured the reading time precisely. It turns out that it takes a little longer to comprehend a sentence that includes emoji than one that doesn't. If the emoji does not directly represent the intended meaning, but another word with the same pronunciation, we need yet a little more time. Based on these results, the team concludes that emoji comprehension consists of two steps: first the image is interpreted, then the word is inferred.
The proportion of UK people reporting eating and drinking plant-based alternative foods such as plant-based milk, vegan sausages and vegetable burgers nearly doubled between 2008 -- 2011 and 2017 -- 2019, according to a new study.
Nanoparticles are omnipresent in our environment: Viruses in ambient air, proteins in the body, as building blocks of new materials for electronics, or in surface coatings. Visualizing these smallest particles is a problem: They are so small that they can hardly be seen under an optical microscope. Researchers have now developed a sensor that not only detects nanoparticles, but also determines their condition and tracks their movements in space.
In a large national survey, adults who struggled with picky eating habits as children overwhelmingly said they benefitted more from positive and encouraging strategies their parents used than forceful or coercive approaches.
New research shows that the role of humans in the extinction dynamics of the woolly mammoth (Mammuthus primigenius) began well before the Holocene epoch, which started 11,700 years ago. “Our research shows that humans were a crucial and chronic driver of population declines of woolly mammoths, having an essential role in the timing and location [...]
Pacific rockfish are among the longest-lived vertebrates -- some species live 200+ years. Yet others live barely 10. Their varied lifespans make rockfish a unique genus in which to pinpoint genes associated with long lifespan. Biologists sequenced and compared the genomes of 88 species and found longevity-related genes involved in living at depth and growing larger, but also an increase in some types of regulatory genes. Longer life also correlates with decreased population sizes.
Geophysicists can use a new model to explain the behavior of a tectonic plate sinking into a subduction zone in the Earth's mantle: the plate becomes weak and thus more deformable when mineral grains on its underside are shrunk in size.
Researchers have discovered that mysterious clusters of proteins found on neurons are calcium-signaling 'hotspots' that activate gene transcription, allowing neurons to produce crucial proteins. The discovery may help shape new research into the role of the hotspots in brain function and potentially lead to new classes of therapeutics.