Using an experimental system involving new genetic technology, researchers analyzed the gene expression signatures of a representative sample of barcoded leukemia cells. After implanting some of the leukemia cells in mice, they discovered that distinct gene expression signatures correlated with the various organs where the cancer cells ended up. They were also able to identify previously unknown genes that are involved in disease progression and chemotherapy resistance, which may offer new targets for treatment.
A new study finds that over the last 30 years, Brazil has undergone a nutrition transition toward a diet higher in ultra-processed foods, and that of food types consumed, these have been the largest contributor to worsening impacts on greenhouse gas emissions, the nation's water footprint and ecological footprint, such as deforestation.
Young people who consider themselves 'multilingual' tend to perform better across a wide range of subjects at school, regardless of whether they are actually fluent in another language, new research suggests. The study of more than 800 pupils in England found a measurable, positive relationship between their personal connection with other languages, and their GCSE exam results in both modern language and non-language subjects. This applied whether or not they actually spoke a second language fluently.
The tendency for most of us when it comes to human wastewater is out of sight, out of mind. Rarely do we consider what happens after we flush that toilet or turn off that tap. However, researchers have turned their attention and considerable computational power to the subject and its impacts on global coastal ecosystems. The results aren't pretty, but they are enlightening.
The ability of cells to move together in harmony is crucial for numerous biological processes in our body, for example, wound healing, or the healthy development of an organism. This movement is made possible by the connections between individual cells. A research team has shown that particularly close connections -- 'tight junctions' -- play an important role in cell movement. In addition, researchers investigated the consequences of losing these connections.
Researchers have provided the first experimental evidence that brain regions can evolve independently of each other during cognitive evolution. This so called mosaic brain evolution was verified empirically in an artificial selection experiment with guppies (Poecilia reticulata) where telencephalon size (but no other regions) differed by 10 percent after only four generations of selection. The findings can have wide implications for the understanding of cognitive evolution in other vertebrates, such as primates and humans.
Researchers have shown that albino mice of the C57BL/6 line are highly susceptible to developing the inflammatory liver condition non-alcoholic steatohepatitis (NASH) when fed a high cholesterol diet. The albino mice carry a mutation in the tyrosinase gene leading to a deficiency of melanin synthesis. NASH is a serious illness in humans, and the identification of the involvement of tyrosinase in NASH development will guide future research into this condition.
Comparing features of a common laboratory fruit fly with its rarer cousin collected from Hawai'i Volcanoes National Park, researchers used CRISPR technology to uncover clues about how high-level control genes called Hox genes shape our appearance.
Researchers at the University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed that a new compound they created reduces the sensation of pain by regulating a biological channel linked to pain.
Scientists have developed a scalable, low-cost method to improve the joining of materials in solid-state batteries, resolving one of the big challenges in the commercial development of safe, long-lived energy storage systems.
Human neurons have a much smaller number of channels that control the flow of ions (such as potassium and sodium) than expected, compared to the neurons of other mammals, according to new research led by MIT neuroscientists; and this reduction in channel density may have helped the human brain evolve to operate more efficiently, allowing [...]
A massive international research effort has led to development of a genetic model for the 'ultimate' chickpea, with the potential to lift crop yields by up to 12 per cent.
The thickness of the brittle lithosphere - the outer portion of a planetary body that fails via fracturing - plays a key role in the geological processes of that body. The properties of both a planet and its host star can influence that thickness, and the potential range of those properties exceeds what researchers see [...]
Discoveries of iguanodontian dinosaurs from the Isle of Wight have previously only been assigned to Iguanodon or Mantellisaurus . The diversity of dinosaurs in the Early Cretaceous of the UK is much greater than previously thought.
Human-caused bird extinctions are driving losses of functional diversity on islands worldwide, and the gaps they leave behind are not being filled by introduced (alien) species, finds a new study.
Researchers have found a new way to detect the virus that causes COVID-19 by testing the air passing through building ventilation systems. The discovery could lead to earlier detection of the virus, improved quarantine protocols, reduced transmission and fewer outbreaks.
The NASA/ESA Hubble Space Telescope has captured this vivid image of NGC 1535, or the Cleopatra’s Eye Nebula. NGC 1535 is a 10.5-magnitude planetary nebula in the constellation of Eridanus. Also referred to as BD-13 842, HD 26847 and IRAS 04119-1251 in various astronomical catalogues, it lies at a distance between 5,500 and 7,500 light-years [...]